Other tests utilizing systems pathology that uses cellular and biologic features of a tumor is experimental and investigational, including use in predicting risk of recurrence in patients with prostate cancer.Other screening tests for prostate cancer, including, but not limited to, alphamethylacyl coenzyme A racemase (AMACR), early prostate cancer antigen, endoglin, E twenty-six (ETS) gene fusions, human kallikrein 2, analysis of prostatic fluid electrolyte composition, interleukin-6, transforming growth factor-beta 1, TMPRSS2:ERG gene fusion, and gene hypermethylation, are experimental and investigational because their clinical utility has not been proven.Routine prostate cancer screening using percent free PSA, free-to-total PSA ratio, and complexed PSA tests.Use of percent free PSA, 4Kscore, Prostate Health Index (PHI), PCA3 score or ConfirmMDx as a first-line screening test for prostate cancer.Testing in the following situations is considered experimental and investigational:.PSA testing meets coverage criteria for follow-up of individuals with a current or previous diagnosis of prostate cancer, and for ongoing monitoring of individuals who have undergone tumor resection or prostatectomy. African-American individuals and individuals with a family history of prostate cancer or individuals with a presence of inherited mutations).
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